A Biomanufacturing laboratory manual focusing on one of three NBC2 Core Production Systems utilizing recombinant cells to make proteins-of-interest. This manual focuses on tissue Plasminogen Activator (tPA) secreting CHO cells. Hands-on equipment and processes covered within include Upstream and Downstream Processing and Quality Control Biochemistry SOPs along with a Quality Assurance Batch Record. This laboratory manual was created and tested by the Northeast Biomanufacturing Center and Collaborative. This NSF ATE funded project is dedicated to building infrastructure for Biomanufacturing education and training, and the workforce.
CHO - tPA Core Production System Lab Manual
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